Chemical Identity
| Name | Semaglutide |
|---|---|
| Synonyms | NN9535, NNC 0113-0217 |
| CAS Number | 910463-68-2 |
| Molecular Formula | C187H291N45O59 |
| Molecular Weight | 4113.58 g/mol |
| Sequence | H-His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(γGlu-2×OEG-C18 diacid)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly-OH |
| Structure Class | Acylated GLP-1(7–37) analogue: Aib8 and Arg34 substitutions, Lys26 side chain derivatized with a C18 fatty diacid via a γGlu–2×OEG linker |
Mechanisms at a Glance
- Full agonist at the GLP-1 receptor, raising cAMP in β-cell models
- Aib substitution at position 8 blocks DPP-4 cleavage
- C18 fatty diacid side chain enables reversible albumin binding
Research Applications
- GLP-1 receptor pharmacology and signalling
- Islet and β-cell insulin secretion studies
- Central appetite-regulation research in rodent models
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. Swirl gently after reconstitution; acylated peptides are prone to aggregation under vigorous agitation. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Semaglutide is the active ingredient in FDA-approved prescription medicines (Ozempic®, Wegovy®, Rybelsus®). The research-grade reference material sold here is not a drug product, is not manufactured under pharmaceutical cGMP, and must not be used as a substitute for any approved medicine. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Semaglutide?
Semaglutide is an acylated analogue of human GLP-1(7–37) engineered for DPP-4 resistance and albumin binding, giving it a half-life of about one week.
What is the CAS number of Semaglutide?
Semaglutide is registered under CAS number 910463-68-2. Its molecular formula is C187H291N45O59 and its molecular weight is 4113.58 g/mol.
How should Semaglutide be stored?
Store lyophilized Semaglutide at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. Swirl gently after reconstitution; acylated peptides are prone to aggregation under vigorous agitation.
Is Semaglutide approved for human use?
Semaglutide is the active ingredient in FDA-approved prescription medicines (Ozempic®, Wegovy®, Rybelsus®). The research-grade reference material sold here is not a drug product, is not manufactured under pharmaceutical cGMP, and must not be used as a substitute for any approved medicine. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
How does semaglutide differ from tirzepatide?
Semaglutide is a selective GLP-1 receptor agonist, while tirzepatide activates both the GIP and GLP-1 receptors. Both carry fatty-diacid side chains for albumin binding — C18 for semaglutide, C20 for tirzepatide.
Why is semaglutide prone to aggregation in solution?
Its fatty-acid side chain promotes self-association, so agitation, air–liquid interfaces and unfavourable pH can drive aggregation; gentle mixing and cold storage help.
Alternative Designations & Synonyms
Semaglutide also appears in the literature and supplier listings under the following names and codes:
- NN9535
- NNC 0113-0217
- GLP-1 receptor agonist
- Acylated GLP-1(7–37) analogue
- Long-acting GLP-1 analogue
References
Lau J et al., J Med Chem 2015; Gabery S et al., JCI Insight 2020; Wilding JPH et al., N Engl J Med 2021; Buckley ST et al., Sci Transl Med 2018.