Chemical Identity
| Name | Mazdutide (IBI362 / LY3305677) |
|---|---|
| Synonyms | IBI362, LY3305677, OXM-3 |
| CAS Number | 2259884-03-0 |
| Molecular Formula | C207H317N45O65 |
| Molecular Weight | 4476.08 g/mol |
| Sequence | His-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Glu-Lys-Lys-Ala-Lys(AEEA-AEEA-γGlu-nonadecanoyl)-Glu-Phe-Val-Glu-Trp-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-NH2 |
| Structure Class | Oxyntomodulin-derived analogue with Aib at position 2, a lipidated lysine at position 20 bearing a double AEEA–γGlu spacer, and a C-terminal amide |
Mechanisms at a Glance
- Dual agonist at the GLP-1 receptor and the glucagon receptor (GCGR)
- Built on an oxyntomodulin scaffold — an endogenous proglucagon product that natively engages both receptors — rather than on GLP-1(7–37)
- Aib at position 2 blocks DPP-4 cleavage at the N-terminus
- A fatty-acyl chain on Lys20, through two AEEA spacers and a γGlu linker, gives albumin binding and once-weekly kinetics
Research Applications
- Studies separating glucagon-receptor from GIP-receptor contributions to incretin pharmacology
- Comparative work against GLP-1-only and GIP/GLP-1 dual agonists
- Oxyntomodulin-analogue structure–activity research
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Mazdutide is not approved by the FDA as a drug for any indication; reporting on approval elsewhere is inconsistent. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Mazdutide?
Mazdutide is a lipidated oxyntomodulin analogue that agonizes the GLP-1 and glucagon receptors. It is not a GLP-2 agonist, despite the supplier shorthand, and its glucagon arm is what distinguishes it from tirzepatide.
What is the CAS number of Mazdutide?
Mazdutide is registered under CAS number 2259884-03-0. Its molecular formula is C207H317N45O65 and its molecular weight is 4476.08 g/mol.
How should Mazdutide be stored?
Store lyophilized Mazdutide at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days.
Is Mazdutide approved for human use?
Mazdutide is not approved by the FDA as a drug for any indication; reporting on approval elsewhere is inconsistent. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
Is mazdutide a GLP-2 agonist?
No. Mazdutide activates the GLP-1 and glucagon receptors. Some supplier catalogs list it as “GLP-2 MZD”, which is an internal product code rather than a statement about receptor selectivity.
How does it differ from tirzepatide?
Both pair GLP-1 agonism with a second receptor, but tirzepatide's partner is GIP and mazdutide's is glucagon. GIP-receptor engagement is associated with insulin secretion and tolerability; the glucagon receptor is associated in the literature with energy expenditure.
Which molecular formula is correct?
The certificate reports C207H317N45O65 at 4476.08 g/mol. Several vendor catalogs list C210H322N46O67 at 4563.06 instead, and disagree on whether the acyl group is nonadecanoic acid or a C20 diacid. The figures on this page follow the certificate.
Alternative Designations & Synonyms
Mazdutide also appears in the literature and supplier listings under the following names and codes:
- IBI362
- LY3305677
- OXM-3
- IBI-362
- LY-3305677
- GLP-2 MZD
References
Ji L et al., Nat Commun 2022 (PMC9561728); phase 1b obesity trial, PubMed 35750681; type 2 diabetes cohort, PubMed 36247927.