Chemical Identity
| Name | Tirzepatide |
|---|---|
| Synonyms | LY3298176 |
| CAS Number | 2023788-19-2 |
| Molecular Formula | C225H348N48O68 |
| Molecular Weight | 4813.45 g/mol |
| Sequence | H-Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Ile-Ala-Gln-Lys(γGlu-2×OEG-C20 diacid)-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
| Structure Class | 39-amino-acid linear peptide based on the native GIP sequence, with Aib at positions 2 and 13 and a C20 fatty diacid on Lys20 via a γGlu–2×OEG linker; C-terminal amide |
Mechanisms at a Glance
- Agonist at GIP and GLP-1 receptors with an imbalanced, GIP-favoured profile
- Favours cAMP signalling over β-arrestin recruitment at the GLP-1 receptor
- Aib at positions 2 and 13 for protease resistance; C20 diacid on Lys20 for albumin binding
Research Applications
- Dual-incretin pathway pharmacology
- Receptor signalling-bias studies
- Diet-induced obesity rodent models
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. Swirl gently after reconstitution; acylated peptides are prone to aggregation under vigorous agitation. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Tirzepatide is the active ingredient in FDA-approved prescription medicines (Mounjaro®, Zepbound®). The research-grade reference material sold here is not a drug product, is not manufactured under pharmaceutical cGMP, and must not be used as a substitute for any approved medicine. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Tirzepatide?
Tirzepatide is a 39-residue synthetic peptide based on the GIP sequence that activates both the GIP and GLP-1 receptors.
What is the CAS number of Tirzepatide?
Tirzepatide is registered under CAS number 2023788-19-2. Its molecular formula is C225H348N48O68 and its molecular weight is 4813.45 g/mol.
How should Tirzepatide be stored?
Store lyophilized Tirzepatide at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. Swirl gently after reconstitution; acylated peptides are prone to aggregation under vigorous agitation.
Is Tirzepatide approved for human use?
Tirzepatide is the active ingredient in FDA-approved prescription medicines (Mounjaro®, Zepbound®). The research-grade reference material sold here is not a drug product, is not manufactured under pharmaceutical cGMP, and must not be used as a substitute for any approved medicine. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
What does "dual agonist" mean for tirzepatide?
It activates two incretin receptors — GIP and GLP-1 — from a single molecule, allowing researchers to study combined incretin signalling.
Is tirzepatide based on GLP-1 or GIP?
Its backbone is based on the native GIP sequence, modified so that it also engages the GLP-1 receptor.
Alternative Designations & Synonyms
Tirzepatide also appears in the literature and supplier listings under the following names and codes:
- LY3298176
- Dual GIP/GLP-1 receptor agonist
- GIP/GLP-1 co-agonist
- Twincretin
References
Coskun T et al., Mol Metab 2018; Willard FS et al., JCI Insight 2020; Jastreboff AM et al., N Engl J Med 2022.