Chemical Identity
| Name | Cagrilintide (AM833) |
|---|---|
| Synonyms | AM833, NNC0174-0833 |
| CAS Number | 1415456-99-3 |
| Molecular Formula | C194H312N54O59S2 |
| Molecular Weight | 4409.01 g/mol |
| Sequence | C20 diacid–γGlu conjugated at Lys1; Cys2–Cys7 intramolecular disulfide; C-terminal amide |
| Structure Class | Long-acting acylated analogue of human amylin; non-selective agonist at amylin (AMY) and calcitonin (CT) receptors |
Mechanisms at a Glance
- Non-selective agonist at amylin (AMY) and calcitonin (CT) receptors — calcitonin-receptor engagement is part of its reported pharmacology, not an off-target effect
- Proline substitutions borrowed from rat amylin suppress the β-sheet formation that makes human amylin fibrillate
- A salt bridge stabilizes the central helix
- An eicosanedioic (C20) diacid conjugated through a γGlu linker at the N-terminal lysine provides albumin binding
Research Applications
- Amylin and calcitonin receptor pharmacology
- Combination studies with GLP-1 analogues, the pairing in which it is most often investigated
- Peptide-aggregation and fibrillation research, where the proline substitutions are the point of interest
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. As with any co-lyophilized blend, reconstitute once and aliquot rather than drawing repeatedly from a single vial. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Neither component is approved by the FDA in this blended form, and cagrilintide is an investigational compound. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Cagrilintide?
Cagrilintide is a long-acting acylated analogue of human amylin that agonizes both amylin and calcitonin receptors. It exists because native amylin aggregates into fibrils too readily to be useful as a long-acting agent.
What is the CAS number of Cagrilintide?
Cagrilintide is registered under CAS number 1415456-99-3. Its molecular formula is C194H312N54O59S2 and its molecular weight is 4409.01 g/mol.
How should Cagrilintide be stored?
Store lyophilized Cagrilintide at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. As with any co-lyophilized blend, reconstitute once and aliquot rather than drawing repeatedly from a single vial.
Is Cagrilintide approved for human use?
Neither component is approved by the FDA in this blended form, and cagrilintide is an investigational compound. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
Why is there no published one-letter sequence?
Novo Nordisk has not released one. Kruse et al. (J Med Chem 2021;64:11183-94, compound 23) describe cagrilintide as human amylin carrying 14E, 17R, 25P, 28P and 29P substitutions plus a C-terminal proline change and an N-terminal C20 fatty-acid conjugate. We publish that description rather than reconstructing a string and presenting it as fact.
Is the disulfide Cys2–Cys7 or Cys3–Cys8?
Both numberings circulate. Cys2–Cys7 fits the 37-residue core; Cys3–Cys8 appears where the fatty-acid–γGlu unit is counted as residue 1. They describe the same bond.
Is cagrilintide a GLP-1 analogue?
No. It is an amylin analogue and acts on a different receptor family entirely. It is frequently studied alongside semaglutide, which is a GLP-1 analogue, and the two are co-formulated as CagriSema.
Alternative Designations & Synonyms
Cagrilintide also appears in the literature and supplier listings under the following names and codes:
- AM833
- NNC0174-0833
- AM-833
- Cagri
References
Kruse T et al., J Med Chem 2021;64:11183-11194; Lau DCW et al., Lancet 2021 (cagrilintide phase 2); Enebo LB et al., Lancet 2021 (cagrilintide with semaglutide).