Chemical Identity
| Name | Ipamorelin |
|---|---|
| Synonyms | NNC 26-0161 |
| CAS Number | 170851-70-4 |
| Molecular Formula | C38H49N9O5 |
| Molecular Weight | 711.85 g/mol |
| Sequence | Aib-His-D-2Nal-D-Phe-Lys-NH2 |
| Structure Class | Synthetic pentapeptide growth hormone secretagogue (GHS-R1a agonist) |
Mechanisms at a Glance
- Selective GHS-R1a agonist acting through phospholipase C and intracellular calcium
- Stimulated GH release in swine without significant ACTH or cortisol increases
- Contains non-natural residues Aib, D-2-naphthylalanine and D-Phe
Research Applications
- Growth hormone secretagogue selectivity studies
- Ghrelin-receptor pharmacology
- Combination studies with GHRH analogues
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. Mod GRF 1-29 is comparatively unstable in solution; prepare working aliquots and keep reconstituted material at 2–8 °C. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Neither CJC-1295 nor ipamorelin is approved by the FDA or any regulatory agency for human use. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Ipamorelin?
Ipamorelin is a synthetic pentapeptide that selectively activates the ghrelin receptor (GHS-R1a) to stimulate growth hormone release.
What is the CAS number of Ipamorelin?
Ipamorelin is registered under CAS number 170851-70-4. Its molecular formula is C38H49N9O5 and its molecular weight is 711.85 g/mol.
How should Ipamorelin be stored?
Store lyophilized Ipamorelin at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. Mod GRF 1-29 is comparatively unstable in solution; prepare working aliquots and keep reconstituted material at 2–8 °C.
Is Ipamorelin approved for human use?
Neither CJC-1295 nor ipamorelin is approved by the FDA or any regulatory agency for human use. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
Why is ipamorelin described as selective?
In early swine studies it released growth hormone without the ACTH and cortisol increases seen with GHRP-6 and GHRP-2.
How is ipamorelin supplied?
We supply it co-lyophilized with CJC-1295 No DAC at 5 mg each, for studies of complementary GHRH and ghrelin-receptor signalling.
Alternative Designations & Synonyms
Ipamorelin also appears in the literature and supplier listings under the following names and codes:
- NNC 26-0161
- Ipamorelin acetate
- Aib-His-D-2Nal-D-Phe-Lys-NH2
- Ghrelin receptor (GHS-R1a) agonist
References
Raun K et al., Eur J Endocrinol 1998; Teichman SL et al., J Clin Endocrinol Metab 2006 (CJC-1295 with DAC).