Chemical Identity
| Name | KPV (α-MSH 11-13) |
|---|---|
| Synonyms | α-MSH (11-13), lysine-proline-valine |
| CAS Number | 67727-97-3 |
| Molecular Formula | C16H30N4O4 |
| Molecular Weight | 342.43 g/mol |
| Sequence | Lys-Pro-Val |
| Structure Class | C-terminal tripeptide fragment of α-melanocyte-stimulating hormone |
Mechanisms at a Glance
- Derived from α-MSH, a 13-residue neuropeptide cleaved from the proopiomelanocortin precursor
- Studied for effects on NF-κB-associated inflammatory signalling
- Lacks the melanocortin-receptor activity responsible for pigmentation, separating the anti-inflammatory signal from the pigmentary one
- At 342.43 g/mol it is among the smallest peptides in this catalog and elutes very early under reverse-phase HPLC
Research Applications
- Inflammatory signalling assays
- Intestinal and epithelial inflammation models
- Component of multi-peptide repair blends, where it is the anti-inflammatory contribution
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. Protect from light and avoid chelating agents such as EDTA, which strip the copper ion from the GHK-Cu component. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
None of the four components is approved by the FDA as a drug for any indication. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is KPV?
KPV is the C-terminal tripeptide of α-melanocyte-stimulating hormone — residues 11 to 13, Lys-Pro-Val. It retains the parent hormone's reported anti-inflammatory activity without its melanocortin-receptor pigmentation effects, which is why the fragment rather than full α-MSH is used in inflammation models.
What is the CAS number of KPV?
KPV is registered under CAS number 67727-97-3. Its molecular formula is C16H30N4O4 and its molecular weight is 342.43 g/mol.
How should KPV be stored?
Store lyophilized KPV at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. Protect from light and avoid chelating agents such as EDTA, which strip the copper ion from the GHK-Cu component.
Is KPV approved for human use?
None of the four components is approved by the FDA as a drug for any indication. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
Why use KPV rather than α-MSH?
α-MSH activates melanocortin receptors and affects pigmentation. KPV is the C-terminal fragment that carries the reported anti-inflammatory activity without that receptor engagement, which makes it the cleaner tool for inflammation work.
Which molecular formula is correct?
C16H30N4O4 at about 342.43 g/mol. One vendor page lists C16H30N6O3, which does not match the weight quoted alongside it.
Where does Aclopiel supply KPV?
As a component of the KLOW blend, alongside GHK-Cu, BPC-157 and TB-500. It is not currently sold on its own.
Alternative Designations & Synonyms
KPV also appears in the literature and supplier listings under the following names and codes:
- α-MSH (11-13)
- lysine-proline-valine
- alpha-MSH 11-13
- Lys-Pro-Val
- Lysine-proline-valine
References
Dalmasso G et al., Am J Physiol Gastrointest Liver Physiol 2008 (KPV); Sikiric P et al., Curr Pharm Des 2018 (BPC-157); Goldstein AL et al., Trends Mol Med 2005 (thymosin β4); Pickart L, Margolina A, Int J Mol Sci 2018 (GHK-Cu).