Chemical Identity
| Name | PT-141 (Bremelanotide) |
|---|---|
| Synonyms | Bremelanotide, PT-141 |
| CAS Number | 189691-06-3 |
| Molecular Formula | C50H68N14O10 |
| Molecular Weight | 1025.18 g/mol |
| Sequence | Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH |
| Structure Class | Cyclic heptapeptide melanocortin analogue (lactam bridge Asp–Lys); free-acid C-terminal metabolite analogue of Melanotan II |
Mechanisms at a Glance
- Agonist at MC4R and MC3R, with additional MC1R activity
- An Asp–Lys lactam bridge constrains its cyclic structure
- Acts on hypothalamic circuits rather than vascular pathways
Research Applications
- Central melanocortin pathway research
- MC4R pharmacology
- Comparative studies with Melanotan II
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Bremelanotide is the active ingredient in an FDA-approved prescription medicine (Vyleesi®). The research-grade reference material sold here is not a drug product, is not manufactured under pharmaceutical cGMP, and must not be used as a substitute for any approved medicine. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is PT-141?
PT-141 (bremelanotide) is a cyclic heptapeptide analogue of α-MSH that acts as a melanocortin receptor agonist, studied for central nervous system melanocortin signalling.
What is the CAS number of PT-141?
PT-141 is registered under CAS number 189691-06-3. Its molecular formula is C50H68N14O10 and its molecular weight is 1025.18 g/mol.
How should PT-141 be stored?
Store lyophilized PT-141 at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days.
Is PT-141 approved for human use?
Bremelanotide is the active ingredient in an FDA-approved prescription medicine (Vyleesi®). The research-grade reference material sold here is not a drug product, is not manufactured under pharmaceutical cGMP, and must not be used as a substitute for any approved medicine. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
How does PT-141 differ from Melanotan II?
They share the same cyclic core; PT-141 has a free-acid C-terminus, whereas Melanotan II is a C-terminal amide.
Which receptors does PT-141 act on?
It is a non-selective melanocortin agonist with activity at MC4R and MC3R, and also MC1R.
Alternative Designations & Synonyms
PT-141 also appears in the literature and supplier listings under the following names and codes:
- Bremelanotide
- PT 141
- PT141
- Melanocortin receptor agonist
- Cyclic α-MSH analogue
References
Pfaus JG et al., Proc Natl Acad Sci USA 2004; Kingsberg SA et al., Obstet Gynecol 2019.