Chemical Identity
| Name | SLU-PP-332 (4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide) |
|---|---|
| Synonyms | SR9861 (reported synonym, unverified), PubChem CID 5338394 |
| CAS Number | 303760-60-3 |
| Molecular Formula | C18H14N2O2 |
| Molecular Weight | 290.32 g/mol |
| Sequence | Acylhydrazone of 4-hydroxybenzohydrazide and 2-naphthaldehyde |
| Structure Class | Synthetic acylhydrazone small molecule; pan-agonist at the oestrogen-related receptors ERRα, ERRβ and ERRγ |
Mechanisms at a Glance
- Pan-agonist at ERRα, ERRβ and ERRγ, with reported EC50 values of roughly 98 nM, 230 nM and 430 nM — ERRα-preferring rather than ERRα-selective
- The ERRs are orphan nuclear receptors: structurally related to the oestrogen receptors but constitutively active and unresponsive to oestradiol
- ERRα regulates a transcriptional programme covering mitochondrial biogenesis and oxidative metabolism that overlaps with the PGC-1α response to endurance exercise
- Lipophilic and water-insoluble; requires a DMSO stock rather than an aqueous one
Research Applications
- Nuclear-receptor transcriptional assays
- Mitochondrial biogenesis and oxidative-metabolism studies
- Comparative work against PGC-1α pathway activators
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. Store the powder at −20 °C, protected from light. Prepare a DMSO stock rather than an aqueous solution. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
SLU-PP-332 is a research chemical and is not approved by the FDA as a drug for any indication. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is SLU-PP-332?
SLU-PP-332 is a synthetic acylhydrazone that agonizes all three oestrogen-related receptors, with the highest potency at ERRα. It is a small molecule, not a peptide, and the oestrogen-related receptors are not oestrogen receptors.
What is the CAS number of SLU-PP-332?
SLU-PP-332 is registered under CAS number 303760-60-3. Its molecular formula is C18H14N2O2 and its molecular weight is 290.32 g/mol.
How should SLU-PP-332 be stored?
Store lyophilized SLU-PP-332 at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. Store the powder at −20 °C, protected from light. Prepare a DMSO stock rather than an aqueous solution.
Is SLU-PP-332 approved for human use?
SLU-PP-332 is a research chemical and is not approved by the FDA as a drug for any indication. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
Why is it called an exercise mimetic?
Because the ERRα transcriptional programme overlaps with the one endurance exercise induces through PGC-1α. That is an argument from transcriptional overlap, not a demonstration that the compound is equivalent to training, and the supporting data are mouse data.
Does it act on oestrogen receptors?
No. Despite the name, the oestrogen-related receptors are orphan nuclear receptors that do not bind oestradiol. One major supplier lists SLU-PP-332 under “estrogen/progestogen receptor agonist” and another lists it as an inhibitor; both contradict the reported pharmacology.
How is it dissolved?
In DMSO. Bacteriostatic water will not dissolve it. Keep the final DMSO concentration below what your model system tolerates.
Alternative Designations & Synonyms
SLU-PP-332 also appears in the literature and supplier listings under the following names and codes:
- SR9861 (reported synonym
- unverified)
- PubChem CID 5338394
- SR9861
- 4-hydroxy-N'-[(E)-naphthalen-2-ylmethylidene]benzohydrazide
References
Billon C et al., J Biol Chem 2023 (ERR agonist characterization); Billon C et al., Nat Commun 2024 (exercise-mimetic phenotype in mice); Sigma-Aldrich product SML3908 technical data.