Chemical Identity
| Name | Tesamorelin (trans-3-hexenoyl-GHRH 1-44) |
|---|---|
| Synonyms | TH 9507, Egrifta, N-[(3E)-1-oxo-3-hexen-1-yl]-somatoliberin |
| CAS Number | 218949-48-5 |
| Molecular Formula | C221H366N72O67S |
| Molecular Weight | 5135.86 g/mol |
| Sequence | (trans-3-hexenoyl)-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-OH |
| Structure Class | Full 44-residue human growth-hormone-releasing hormone sequence with a trans-3-hexenoyl group on the N-terminal tyrosine |
Mechanisms at a Glance
- Agonist at the GHRH receptor on pituitary somatotrophs — a different receptor from the ghrelin receptor (GHS-R1a) that ipamorelin and similar secretagogues act on
- The trans-3-hexenoyl group on Tyr1 blocks the DPP-4 cleavage that degrades native GHRH within minutes
- Retains all 44 residues, unlike the truncated GHRH(1-29) analogues such as CJC-1295 No DAC, which keep only the receptor-binding core
- Useful as a comparator for studies on the contribution of the C-terminal region
Research Applications
- GHRH-receptor pharmacology and signalling
- Comparative studies against truncated GHRH(1-29) analogues and against ghrelin mimetics
- Analytical reference material for long-peptide HPLC and LC-MS method development
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Tesamorelin is the active ingredient in an approved prescription product in some jurisdictions, but the material on this page is a research reference compound and is not supplied as a medicine. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is Tesamorelin?
Tesamorelin is the full 44-residue sequence of human growth-hormone-releasing hormone with a trans-3-hexenoyl group on the N-terminal tyrosine. At 5135.86 g/mol it is the largest peptide in this catalog.
What is the CAS number of Tesamorelin?
Tesamorelin is registered under CAS number 218949-48-5. Its molecular formula is C221H366N72O67S and its molecular weight is 5135.86 g/mol.
How should Tesamorelin be stored?
Store lyophilized Tesamorelin at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days.
Is Tesamorelin approved for human use?
Tesamorelin is the active ingredient in an approved prescription product in some jurisdictions, but the material on this page is a research reference compound and is not supplied as a medicine. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
How does tesamorelin differ from ipamorelin?
They act on different receptors. Tesamorelin is a GHRH analogue acting at the GHRH receptor; ipamorelin is a pentapeptide ghrelin mimetic acting at GHS-R1a. Both reach the same endocrine axis by separate routes, which is why they are sometimes studied together.
Why modify the N-terminus?
Native GHRH is cleaved rapidly by DPP-4 at its N-terminus. The hexenoyl group blocks that cleavage. It is the single modification that makes the full-length sequence practical to work with, and it is a different strategy from truncating the peptide to its binding core.
Which registry number applies?
CAS 218949-48-5 is the primary one. At least one database also lists 804475-66-9, and acetate-salt listings carry additional mass over the 5135.86 g/mol free base.
Alternative Designations & Synonyms
Tesamorelin also appears in the literature and supplier listings under the following names and codes:
- TH 9507
- Egrifta
- N-[(3E)-1-oxo-3-hexen-1-yl]-somatoliberin
- TH-9507
- N-[(3E)-1-Oxo-3-hexen-1-yl]-somatoliberin
- TESA
References
Falutz J et al., N Engl J Med 2007;357:2359-2370; Stanley TL et al., JAMA 2014;312:380-389; Egrifta prescribing information (Theratechnologies).