Chemical Identity
| Name | BPC-157 (Body Protection Compound-157) |
|---|---|
| Synonyms | PL 14736, PL-10, Bepecin |
| CAS Number | 137525-51-0 |
| Molecular Formula | C62H98N16O22 |
| Molecular Weight | 1419.53 g/mol |
| Sequence | Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val |
| Structure Class | Synthetic linear pentadecapeptide (15 amino acids), partial sequence of human gastric juice protein BPC |
Mechanisms at a Glance
- Up-regulates VEGFR2 and activates VEGFR2–Akt–eNOS signalling in endothelial models
- Promotes fibroblast migration and spreading via FAK–paxillin phosphorylation
- Modulates the nitric oxide system and increases growth hormone receptor expression in tendon fibroblasts
Research Applications
- Tendon, ligament and muscle injury models
- Gastric mucosal lesion and fistula models
- Angiogenesis and endothelial migration assays
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
BPC-157 is not approved by the FDA or any regulatory agency for human use. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is BPC-157?
BPC-157 is a synthetic 15-amino-acid peptide derived from a protective protein in human gastric juice, studied primarily in preclinical models of tissue repair and gastrointestinal protection.
What is the CAS number of BPC-157?
BPC-157 is registered under CAS number 137525-51-0. Its molecular formula is C62H98N16O22 and its molecular weight is 1419.53 g/mol.
How should BPC-157 be stored?
Store lyophilized BPC-157 at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days.
Is BPC-157 approved for human use?
BPC-157 is not approved by the FDA or any regulatory agency for human use. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
How does BPC-157 differ from TB-500?
BPC-157 is studied mainly for growth-factor receptor and nitric-oxide signalling, while TB-500 (Thymosin β4) regulates the actin cytoskeleton by sequestering G-actin. Both are associated with cell migration and angiogenesis in preclinical models, but through different pathways.
Why is BPC-157 studied in gastrointestinal models?
It originates from a gastric juice protein and is reported to be stable in gastric juice, so much of the early research examined mucosal protection in rodent lesion models.
Alternative Designations & Synonyms
BPC-157 also appears in the literature and supplier listings under the following names and codes:
- PL 14736
- PL-10
- Bepecin
- BPC 157
- BPC157
- Body Protection Compound-157
- Body Protection Compound
- Pentadecapeptide BPC 157
References
Chang C-H et al., J Appl Physiol 2011; Hsieh M-J et al., J Mol Med 2017; Seiwerth S et al., Curr Pharm Des 2018; Sikiric P et al., Curr Neuropharmacol 2016; Sebecic B et al., Bone 1999; Staresinic M et al., J Orthop Res 2006.