Chemical Identity
| Name | CJC-1295 No DAC (Modified GRF 1-29) |
|---|---|
| Synonyms | Mod GRF (1-29), tetrasubstituted GRF (1-29) |
| CAS Number | Not assignedNo CAS number is widely registered for the no-DAC form. 863288-34-0 is frequently mis-cited; it refers to CJC-1295 with DAC. |
| Molecular Formula | C152H252N44O42 |
| Molecular Weight | 3367.97 g/mol |
| Sequence | Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2 |
| Structure Class | GHRH(1-29) analogue with D-Ala2, Gln8, Ala15 and Leu27 substitutions; no Drug Affinity Complex (DAC) |
Mechanisms at a Glance
- Agonist at the pituitary GHRH receptor (cAMP signalling)
- D-Ala2, Gln8, Ala15 and Leu27 substitutions improve DPP-4 and chemical stability
- No Drug Affinity Complex, so its half-life is short — on the order of 30 minutes
Research Applications
- Pulsatile growth hormone release models
- Hypothalamic–pituitary–somatotropic axis research
- Combination studies with GHS-R1a agonists
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. Mod GRF 1-29 is comparatively unstable in solution; prepare working aliquots and keep reconstituted material at 2–8 °C. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
Neither CJC-1295 nor ipamorelin is approved by the FDA or any regulatory agency for human use. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is CJC-1295 No DAC?
CJC-1295 without DAC (Modified GRF 1-29) is a 29-residue GHRH analogue with four amino-acid substitutions that improve its stability over sermorelin.
What is the molecular weight of CJC-1295 No DAC?
Its molecular formula is C152H252N44O42 and its molecular weight is 3367.97 g/mol.
How should CJC-1295 No DAC be stored?
Store lyophilized CJC-1295 No DAC at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days. Mod GRF 1-29 is comparatively unstable in solution; prepare working aliquots and keep reconstituted material at 2–8 °C.
Is CJC-1295 No DAC approved for human use?
Neither CJC-1295 nor ipamorelin is approved by the FDA or any regulatory agency for human use. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
What is the difference between CJC-1295 with and without DAC?
The DAC version carries a maleimide-linked albumin-binding group that gives it a multi-day half-life; the no-DAC form (Mod GRF 1-29) is short-acting.
Does CJC-1295 No DAC have a CAS number?
No CAS number is widely registered for the no-DAC form. 863288-34-0 is often quoted but refers to CJC-1295 with DAC.
Alternative Designations & Synonyms
CJC-1295 No DAC also appears in the literature and supplier listings under the following names and codes:
- Mod GRF (1-29)
- tetrasubstituted GRF (1-29)
- CJC 1295
- CJC-1295 without DAC
- Modified GRF (1-29)
- Mod GRF 1-29
- Tetrasubstituted GRF (1-29)
- GHRH (1-29) analogue
References
Raun K et al., Eur J Endocrinol 1998; Teichman SL et al., J Clin Endocrinol Metab 2006 (CJC-1295 with DAC).