Chemical Identity
| Name | ARA-290 (Cibinetide) |
|---|---|
| Synonyms | Cibinetide, pHBSP, EPO helix-B surface peptide |
| CAS Number | 1208243-50-8 |
| Molecular Formula | C51H84N16O21 |
| Molecular Weight | 1257.30 g/mol |
| Sequence | Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH |
| Structure Class | 11-residue linear peptide derived from the helix-B surface of erythropoietin, with an N-terminal pyroglutamate |
Mechanisms at a Glance
- Described as selectively activating the EPOR/CD131 heteroreceptor — the innate repair receptor — without activating EPOR homodimers
- That receptor split is the entire design rationale: it separates erythropoietin's reported tissue-protective signalling from its effect on red-cell production
- Built from the face of the EPO molecule that does not contact the homodimeric receptor, which is why it is reported to lack erythropoietic activity
- The N-terminal pyroglutamate is a cyclized glutamate, which affects how the peptide behaves in sequencing and mass spectrometry
Research Applications
- Neuropathic pain and small-fibre neuropathy models
- Inflammatory and ischaemic tissue-injury research
- Studies separating EPO's tissue-protective signalling from erythropoiesis
Handling & Storage
Store lyophilized material at −20 °C, desiccated and protected from light; after reconstitution, keep solutions at 2–8 °C and use within 28 days. See our storage and stability guide and reconstitution guide for technique and diluent selection.
Regulatory Status
ARA-290 is an investigational compound and is not approved by the FDA as a drug for any indication. Material supplied by Aclopiel is strictly for in-vitro laboratory research and is not for human or veterinary use.
Frequently Asked Questions
What is ARA-290?
ARA-290 is an 11-residue peptide derived from the helix-B surface of erythropoietin, carrying an N-terminal pyroglutamate. It is a single peptide, not a blend, despite appearing under “blends” in some supplier catalogs.
What is the CAS number of ARA-290?
ARA-290 is registered under CAS number 1208243-50-8. Its molecular formula is C51H84N16O21 and its molecular weight is 1257.30 g/mol.
How should ARA-290 be stored?
Store lyophilized ARA-290 at −20 °C, desiccated and protected from light. After reconstitution, keep it at 2–8 °C and use it within 28 days.
Is ARA-290 approved for human use?
ARA-290 is an investigational compound and is not approved by the FDA as a drug for any indication. Aclopiel supplies it strictly for in-vitro laboratory research; it is not for human or veterinary use.
Is ARA-290 a blend?
No. It is a single 11-residue peptide. Some supplier catalogs file it under blends, which is simply a cataloguing error.
Why do the sequence notations differ?
The N-terminal residue is pyroglutamate, a cyclized glutamate. Listings that write the sequence as QEQLERALNSS have expanded it to glutamine; Pyr-EQLERALNSS describes the same molecule.
Which identifiers are reliable?
Unusually few. Three molecular formulas and two CAS numbers circulate across supplier catalogs, all paired with a mass near 1257 g/mol. Verify identity by mass spectrometry against the batch certificate rather than relying on catalog data.
Alternative Designations & Synonyms
ARA-290 also appears in the literature and supplier listings under the following names and codes:
- Cibinetide
- pHBSP
- EPO helix-B surface peptide
- ARA290
References
Brines M et al., Proc Natl Acad Sci USA 2008;105:10925-10930; Dahan A et al., Mol Med 2013;19:334-345; Culver DA et al., Am J Respir Crit Care Med 2017 (sarcoidosis small-fibre neuropathy).