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Splenomegaly, enlarged liver. Decreased levels of platelets and leukocytes in the blood. Pathology develops in a disseminated type. Separately, it should be said about the symptoms of plavix online in HIV-infected people. These patients have an acute fever, significant enlargement of the lymph nodes, liver and spleen, cough and infiltrates in the lungs. In this case, only 20% of patients survive. Patients with AIDS have an even lower survival rate.

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About plavixIn children, histoplasmosis is diagnosed even more often than in adults, while the disease occurs even in the smallest children and is characterized by the following features. High temperature (38-39В�C). Paleness or yellowness of the skin. Weight loss. Histoplasmosis is caused by the fungus Histoplasma capsulatum. This fungus is common in tissue or cultured form. If the fungus is already inside the body, then this is a tissue form that actively affects the reticuloendothelial system (lymph nodes, liver, spleen), hence another name for the disease - reticuloendothelial cytoplasmosis. The cultural form of the fungus lives outside the body at moderate temperatures (up to 30 В� C) in water, moist soil, wells, caves, abandoned buildings, etc. Additional spread of the fungus occurs with the droppings of infected birds (pigeons, geese, chickens) and animal feces (cats, dogs, rabbits).

Chronic disseminated histoplasmosis is characterized by a progressive course. initially manifested by a low temperature and symptoms of plavix pills. A person becomes infected by airborne dust if he inhales the cells of the fungus with dust particles. Usually, infection occurs during earthworks in construction, geology or agriculture. Accordingly, the greatest risk of histoplasmosis in geologists, builders, miners, tourists, farmers, residents of rural areas. But there is no direct infection of a person from other people or animals.

When a person inhales earthen dust, the spores of the fungus settle in the lungs, then, together with the lymph flow, they enter the lymph nodes, contributing to their inflammation. The fungus causes a granulomatous process that leads to necrosis, ulcers in the lungs and lymph nodes. When the fungus enters the bloodstream, sensitization (allergic reaction) of the body occurs. Usually it all ends there, but often the fungus spreads throughout the body and affects all internal organs, which causes a threat to human life, especially if the patient suffers from AIDS and his immune system is weakened. The incubation period of the disease can last from 5 to 30 days, but the faster histoplasmosis manifested itself, the more severe its course.

In most cases, the diagnosis of histoplasmosis is very difficult, especially if the patient lives in an area where this disease is extremely rare. When symptoms of histoplasmosis appear, patients usually turn to a general practitioner, pulmonologist, or infectious disease specialist. To establish the correct diagnosis, it is necessary to buy clopidogrel online an analysis of blood, urine, feces, sputum. Serological diagnostic methods, bronchus biopsy, intradermal test with histoplasmin are also used.

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Differential diagnosis is carried out with tuberculosis, atypical pneumonia, ornithosis, mycoplasmosis, blastomycosis, lymphogranulomatosis, sepsis, etc. Patients with asymptomatic histoplasmosis or mild disease usually do not receive antifungal drugs because these drugs are toxic. Therefore, they are limited to symptomatic therapy, histoplasmin and vitamins. With histoplasmosis of the eyes, local corticosteroids are used, desensitizing therapy with histoplasmin, and photocoagulation are performed. Also, patients are prescribed antihistamines and vitamin preparations. In severe forms of histoplasmosis, treatment is carried out with the help of azole drugs - ketoconazole, itraconazole, amphotericin B, amphoglucamine.

Amphotericin B is prescribed at a dose of 1000 units per day per 1 kg of the patient's body weight, the drug is administered intravenously for 4 hours. Usually, the initial dosage does not exceed 100 units / kg of body weight in order to identify individual adverse reactions, then the dosage is increased. The course of treatment clopidogrel lasts 1-2 months. In chronic histoplasmosis, the course is repeated.

Amphoglucamine is a water-soluble preparation of amphotericin B, it is less toxic and comes in tablets (usually 10 or 40 tablets per pack). It is used at 200,000 IU 2 times a day after meals, gradually increase the dose to 500,000 IU. The course of treatment is 3-4 weeks. During the course, it is necessary to order plavix online the protein in the urine, since the drug is toxic to the kidneys.